pdb-l: Minimum length of Protein Sequence

Kevin Karplus karplus at soe.ucsc.edu
Mon Jan 10 07:26:24 PST 2011


Naman asked

> What should be the *minimum length of Protein Sequence* ??  
> And minimum how many Amino Acid are necessary to Make a Protein
> Sequence ?

There is no clear boundary below which a peptide sequence is not a
protein.

Ususally peptide sequences shorter than about 40 amino acids do not
form independently folding proteins with a hydrophobic core, though
ones stabilized by disulphide bonds are not uncommon.  The smallest
known protein with a hydrophobic core is the 20-residue TRP cage
domain.

------------------------------------------------------------
Kevin Karplus 	karplus at soe.ucsc.edu	http://www.soe.ucsc.edu/~karplus
Professor of Biomolecular Engineering, University of California, Santa Cruz
Graduate Director, Biomolecular Engineering and Bioinformatics
(Senior member, IEEE)	(Board of Directors, ISCB)
Editorial Board, Bioinformatics (Oxford University Press)
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